Tesofensine

Tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor which was originally studied for its effect on Parkinson’s and Alzheimer’s. Unfortunately, its exploration for these indications were limited because the research subjects starting losing too much weight. Since then, tesofensine has been studied as a way to treat obesity via its ability to reduce appetite. This molecular compound indirectly stimulates the cholinergic system and showed to be more successful than other weight loss agents. Tesofensine (TE) increases transmission of 3 monoaminergic neurotransmitters in the brain. These neurotransmitters are serotonin, norepinephrine, and dopamine which help regulate energy balance and are linked to obesity and depression. On average, its 6-month weight loss results from a phase 2b clinical trial resulted in a weight loss of around 25 pounds. TE research has shown a pronounced effect on appetite sensations and a slight effect on energy expenditure. Both effects can contribute to the strong weight reducing

Properties

• Chemical Formula: C17H23Cl2NO
• Molecular Mass: 328.3
• Synonyms: NS-2330, UNII-BLH9UKX9V1, BLH9UKX9V1, ZINC3953158
• CAS Number: 195875-84-4
• PubChem:11370864
• Total Amount of the Active Ingredient: 250 mcg/60 capsules
• Shelf Life: 36 months

Product Quality

Lab tests are occasionally published on the website.

You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:

• Cost of HPLC test
• Total amount of the order + shipping fee

Peer-Reviewed Studies 

• Weight loss produced by Tesofensine in patients with Parkinson’s or Alzheimer’s disease

Arne Astrup, Dieter H Meier, Birgit O Mikkelsen, John S Villumsen, Thomas M Larsen

The Obesity Society Volume16, Issue6 June 2008 Pages 1363-1369