Phenibut is a psychoactive substance that was developed in Russia in the 1960s1. It is similar in structure to the neurotransmitter GABA (gamma-aminobutyric acid) and acts as a GABA-mimetic, primarily at GABA(B) and, to some extent, at GABA(A) receptors. Phenibut is marketed as a supplement for anxiety, relaxation, sleep, as well as to help manage symptoms of depression and post-traumatic stress disorder (PTSD). Phenibut is legal to possess in the United States, but it is not approved as a licensed pharmaceutical drug by the FDA.
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Formation of the conditioned reflex in the Passive Avoidance Test in mice
The Passive Avoidance Test is a fear-aggravated test used to evaluate learning and memory in rodent models of CNS disorders. Phenibut has been shown to impact memory and facilitate the formation of the conditioned reflex in the Passive Avoidance Test in mice. In a study, phenibut-treated mice had significantly higher latency times, indicating that they could remember which chamber was conditioned with adverse stimuli. While the control mice had a latency of 154 +/- 91 seconds to enter into the dark chamber, the mice receiving Phenibut at 5 mg/kg i.p. had a latency of 285 +/- 89 seconds. The study suggests that Phenibut can impact memory and facilitate the formation of the conditioned reflex in mice.
Stimulates dopamine production and the prevalence of its metabolites
The study found that a single dose of Phenibut stimulates dopamine production and the prevalence of its metabolites, similar to alcohol. It suggests that Phenibut may have similar effects on the brain as alcohol. It has shown to stimulate dopamine receptors in the brain, creating a simultaneously relaxing and euphoric effect.
However, it is important to note that the dependence potential of Phenibut has not been studied in animals. Overall, while there are some studies examining the effects of Phenibut on animals, more research is needed to fully understand its mechanisms of action and potential risks.